Cyclic nucleotide concentrations in asbestos-induced rat peritoneal mesothelioma
| Autor: | D.A. Cole, C.W. Frank, E.S. Meek, R.H. Stevens, L.A. Will, K.J. Donham |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Mesothelioma medicine.medical_specialty Guanosine Biology medicine.disease_cause Biochemistry chemistry.chemical_compound Cyclic nucleotide Internal medicine Chrysotile Cyclic AMP medicine Animals Cyclic GMP Peritoneal Neoplasms General Environmental Science Asbestos Neoplasms Experimental medicine.disease Adenosine Rats Endocrinology chemistry Cancer cell Peritoneal mesothelioma Carcinogenesis Intracellular medicine.drug |
| Zdroj: | Environmental Research. 19:442-448 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(79)90069-0 |
| Popis: | Peritoneal mesotheliomas were induced through the intraperitoneal administration of Rhodesian chrysotile “A” to weanling male Holtzman rats. The intracellular concentrations of adenosine 3′,5′-cyclic monophosphate and guanosine 3′,5′-cyclic monophosphate were found to be significantly less than the levels measured in comparable control tissues obtained from age-matched animals that had been similarly administered charcoal instead of the asbestos. The calculated molar ratio of cAMP to cGMP was identical in tumors and control tissue implying that the two cyclic nucleotides were diminished by a constant factor in the tumor tissue. However, if tumorigenesis is related to cAMP cGMP balance within the cancer cell, then in these apparently noninvasive lesions such an equilibrium exists as is found in cells of normal mesentery. These results indicate that asbestos-induced mesotheliomas are similar to other cancerous tissues of the digestive tract in that they contain less of the adenosine cyclic nucleotide than the normal tissue. The findings of this study suggest the possible loss of important cellular regulatory mechanisms in tumors induced by an important environmental carcinogen. |
| Databáze: | OpenAIRE |
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