Biological markers and cardiac remodelling following the myocardial infarction
| Autor: | Vasiliy V. Kashtalap, O. M. Polikutina, Evgenya Uchasova, Y. S. Slepynina, Olga Gruzdeva, Olga Barbarash, O E Akbasheva, Victoria Karetnikova, A. A. Shilov, Yulia Dyleva |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Aging medicine.medical_specialty medicine.drug_class Myocardial Infarction Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans In patient Myocardial infarction Pathological Aged Ventricular Remodeling business.industry Cell Biology Atrial Remodeling Middle Aged medicine.disease myocardial infraction Interleukin-1 Receptor-Like 1 Protein Peptide Fragments NT-proBNP Cardiology growth stimulating factor ST2 Female postinfarction remodelling business Biomarkers Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Aim To assess growth stimulating factor ST2 and N-terminal pro b-type natriuretic peptide (NT-proBNP) levels in the sera of myocardial infraction (MI) patients, and their correlation with the adaptive and maladaptive variants of cardiac remodelling. Methods 87 patients (65 male, 22 females; 67±8.36 years) with ST-elevated MI were included in this study, and 67 patients had an adaptive, physiological, while 20 patients had a maladaptive, pathological variant of myocardium remodelling. Results On day 1, ST2 and NT-proBNP levels were shown to increase 2.4 and 4.5 folds, respectively, compared with those in the control. ST2 levels in patients with maladaptive remodelling were 1.5-fold higher than those in the adaptive remodelling group. On day 12, a decrease in ST2 levels was observed in both groups. NT-proBNP levels increased 1.8 folds in both groups on day 1, compared with those in the controls. Increased ST2 levels on day 1 after MI were shown to increase the risk of maladaptive remodelling 4.5 folds, while high NT-proBNP levels increased this risk 2.3 times. Conclusions ST2 level determination allows us to predict the risk of maladaptive remodelling with a higher sensitivity and specificity than using NT-proBNP levels. |
| Databáze: | OpenAIRE |
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