Influence of orthodontic loading on biomarkers levels around miniscrews
| Autor: | Alice Spitz, Lincoln Issamu Nojima, Ricardo Teles |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Vascular Endothelial Growth Factor A Adolescent Tooth Movement Techniques VEGF receptors Inflammatory response Chemokine CXCL1 Bone Screws Crevicular fluid 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Immediate loading Granulocyte Colony-Stimulating Factor Orthodontic Anchorage Procedures Medicine Humans General Dentistry Orthodontics Inflammation biology business.industry Interleukins 030206 dentistry Cell Biology General Medicine Vascular endothelial growth factor 030104 developmental biology Otorhinolaryngology chemistry biology.protein Female Implant business Biomarkers |
| Zdroj: | Archives of oral biology. 112 |
| ISSN: | 1879-1506 |
| Popis: | The aim of this study was to evaluate the levels of Interleukin-1α (IL-1α), Interleukin-1β (IL-1β), Interleukin-1 receptor antagonist (IL-1Ra), Interleukin-10 (IL-10), Interleukin-13 (IL-13), Vascular endothelial growth factor (VEGF), Granulocyte-colony stimulating factor (G-CSF), and Growth related oncogene (GRO) in the peri-miniscrew implant crevicular fluid (MICF) under orthodontic loading.The study sample comprised 14 miniscrews immediately loaded and 17 unloaded ones. A load of 200gF was immediately applied to the miniscrews in the loaded group after the placement surgery. Peri-miniscrew implant crevicular fluid was collected at baseline, at day 7, and at day 21. The levels of the biomarkers were measured using a multiplexed bead immunoassay. Intergroup comparisons were made using Mann-Whitney test. Friedman and Dunn's multiple comparison tests were used to evaluate intragroup differences over time.Although no statistical differences were observed between the groups at any time point for any of the 8 biomarkers evaluated, there was a statistically significant increase (p0.02) in the levels of all the biomarkers over time on both groups.An immediate loading of 200gF does not alter the balance in the inflammatory response in peri-miniscrew tissues. |
| Databáze: | OpenAIRE |
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