The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers
| Autor: | Elias Gialafos, Konstantinos Vemmos, Panagiotis Iliopoulos, Christopher Konialis, Birgitta Hagnefelt, Sophia Karapanou, Constantinos Pangalos, Konstantinos Spengos, Nikolaos Zakopoulos |
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| Rok vydání: | 2015 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Heterozygote Apolipoprotein B Genotype Medicine (miscellaneous) Coronary Disease Disease 030204 cardiovascular system & hematology Gastroenterology Polymorphism Single Nucleotide Risk Assessment General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Apolipoproteins E Gene Frequency Ischemia Risk Factors Internal medicine Internal Medicine medicine Humans Pharmacology (medical) Genetic Predisposition to Disease Risk factor Allele Allele frequency Genetics (clinical) Alleles Aged Analysis of Variance biology Greece business.industry Middle Aged 030227 psychiatry Stroke Methylenetetrahydrofolate reductase Reviews and References (medical) Cohort biology.protein Female business |
| Zdroj: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 25(3) |
| ISSN: | 1899-5276 |
| Popis: | BACKGROUND Although several studies in various countries have indicated that the presence of the E4 allele of the apolipoprotein-E (APOE) gene is a risk factor for ischemic cerebrovascular disease, the strength of this association still remains a matter of debate. OBJECTIVES The aim of the study was to determine the frequency of the APOE E4 allele and various other gene polymorphisms in in a well-characterized sample of Greek patients and to evaluate the potential associations with the risk of ischemic stroke (IS) and coronary heart disease (CHD). MATERIAL AND METHODS A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD). A statistical analysis was performed using univariate and multivariate logistic regression models. RESULTS No significant association was found regarding most gene polymorphisms and the presence of IS or CHD in the patient cohort. However, the APOE E4 allele frequency was significantly higher (p = 0.02) among patients with ischemic stroke (IS) or IS + CHD (12.7%) when compared to the controls (5.1%). More accurately, E4 carriers had 2.66 and 2.71 times greater likelihood of IS or IS + CHD than non-carriers, respectively (OR = 2.66, 95% CI 1.39-5.07, OR = 2.71, 95% CI 0.98-7.48). CONCLUSIONS In contrast to some previous studies, these results support the role of the APOE E4 allele as an independent risk factor for ischemic stroke and ischemic coronary heart disease among Greek patients. |
| Databáze: | OpenAIRE |
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