A Randomized Control Trail of Stepwise Treatment with Fluticasone Propionate Nasal Spray and Fexofenadine Hydrochloride Tablet for Seasonal Allergic Rhinitis
| Autor: | Eiko Ito, Keisuke Masuyama, Tomokazu Matsuoka, Takeo Nakayama, Zensei Matsuzaki, Atsushi Okamoto, Goro Takahashi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy medicine.medical_specialty medicine.medical_treatment seasonal allergic rhinitis Fluticasone propionate law.invention histamine antagonists Randomized controlled trial law Internal medicine Anti-Allergic Agents medicine Humans Immunology and Allergy Fluticasone intranasal steroids business.industry Rhinitis Allergic Seasonal Cedar pollinosis Nasal Sprays General Medicine Middle Aged initial drug Fexofenadine Hydrochloride Androstadienes Reverse order Treatment Outcome back-up drug Nasal spray Anesthesia Pollen Female Nasal administration Terfenadine lcsh:RC581-607 business Tablets medicine.drug |
| Zdroj: | Allergology International, Vol 61, Iss 1, Pp 155-162 (2012) |
| ISSN: | 1323-8930 |
| Popis: | Background: In Japan, oral antihistamines are frequently used as the initial treatment for seasonal allergic rhinitis (SAR), and intranasal steroids are added when nasal symptoms worsen. This study aimed to evaluate whether starting treatment with fluticasone propionate nasal spray (FP) from the beginning of pollinosis symptoms and adding fexofenadine hydrochloride tablet (FEX) when SAR is aggravated could achieve improved amelioration of nasal symptoms throughout the pollen season in comparison with a treatment that involves starting with FEX and later adding FP. Methods: In this pragmatic, randomized, open-label, parallel-group trial, 51 Japanese cedar pollinosis patients (age, 16–85 years) were randomly divided and administered FP 100 mcg twice daily as an initial drug with FEX 60mg twice daily as an additional drug and the same treatment in the reverse order. Nasal symptoms were evaluated in a daily dairy using a 4-point scale. The primary outcome was area under curve of the line representing the daily total nasal symptom score in the pollen season on a graph. Results: Initial treatment with FP was significantly (P=0.0015) more effective than initial treatment with FEX in improving the primary outcome. The average daily total nasal symptom score in the initial treatment with FP group was better than that in the initial treatment with FEX group throughout the pollen season. Conclusions: Initiating treatment with FP and adding FEX might lead to improved outcomes for nasal symptoms in comparison with the same drugs administered in the reverse order. |
| Databáze: | OpenAIRE |
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