Progress of titanium strut for cervical reconstruction with nano-graphene oxide loaded hydroxyapatite/polyamide composite and interbody fusion after corpectomy with anterior plate fixation
| Autor: | Hailong Tian, Hongli Pang, Shaobo Qiu, Yu-Qiang Wang, Ning Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Materials science Biocompatibility medicine.medical_treatment Composite number Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) chemistry.chemical_element Biocompatible Materials 02 engineering and technology Osseointegration Cell Line Nanocomposites 03 medical and health sciences 0302 clinical medicine stomatognathic system Materials Testing medicine Humans Corpectomy Fixation (histology) Titanium Biomaterial General Medicine Middle Aged 021001 nanoscience & nanotechnology Nylons Durapatite chemistry 030220 oncology & carcinogenesis Cervical Vertebrae Female Graphite Implant 0210 nano-technology Biotechnology Biomedical engineering |
| Zdroj: | Artificial Cells, Nanomedicine, and Biotechnology. 47:3094-3100 |
| ISSN: | 2169-141X 2169-1401 |
| DOI: | 10.1080/21691401.2019.1637883 |
| Popis: | To evaluate the long-term biological and clinical results of anterior cervical corpectomy and fusion (ACCF) with a synthesized nano-graphene oxide (nano-GO) loaded hydroxyapatite/polyamide (HAp/PA) strut in the implantation treatment of cervical reconstruction. Bio-ceramic Hydroxyapatite (HAp) combined with suitable polymer matrix is one of the furthermost naturally occurring biomaterial form for hard tissues and dental regeneration therapies due to their bone-like chemical compositional structure and biocompatibility similarity to native bone of the human body. In the present investigation, the development of nano-GO loaded HAp/PA composite strut for anterior cervical reform and fusion properties after corpectomy is studied. Forty patients who suffered from first or second level ACCF, treated with nano-GO loaded HAp/PA strut, were investigated. At final follow-up period, the fusion rate was 99%, and the subsidence value of the prepared strut was 5%. The results of cell viability and proliferation analyses indicated that the prepared nanocomposites did not exhibit non-cytotoxicity with the human cells. In summary, the satisfactory consequences in this research work designated that the nano-GO loaded HAp/PA strut was an active implant in the treatment of cervical reconstruction. Furthermore, the osteoconductive and osseointegration properties of the prepared struts need to be analyzed and optimized for future bio-medical usages. |
| Databáze: | OpenAIRE |
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