Long-Term follow-up of Standard Photodynamic Therapy with Standardized Small Spot Size for Diffuse Retinal Pigment Epitheliopathy
| Autor: | Aggeliki Androu, Ioannis Ladas, Irini Chatziralli, Panagiotis Theodossiadis, Alexander Rouvas, Eleni Nikita |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Porphyrins Visual acuity genetic structures Long term follow up medicine.medical_treatment Visual Acuity Photodynamic therapy Retinal Pigment Epithelium chemistry.chemical_compound Optics Recurrence Ophthalmology medicine Humans Fluorescein Angiography Retinal pigment epitheliopathy Adverse effect Retrospective Studies Photosensitizing Agents business.industry Lasers Verteporfin Retinal Retrospective cohort study General Medicine Middle Aged eye diseases Treatment Outcome Central Serous Chorioretinopathy Photochemotherapy chemistry Female medicine.symptom business Tomography Optical Coherence Follow-Up Studies medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 25:229-234 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.5301/ejo.5000541 |
| Popis: | Purpose To evaluate the long-term efficacy and safety of standard-fluence photodynamic therapy (PDT) with verteporfin using the minimum PDT spot size in patients with diffuse retinal pigment epitheliopathy (DRPE). Methods This is a retrospective study of 67 DRPE cases treated with PDT using a standardized minimum spot size of 850 μm. Indocyanine green angiography (ICGA) was used to guide and determine the outcome of PDT treatment. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), recurrences, and adverse events were recorded and analyzed. Results The mean follow-up period of the study was 35.8 ± 16.6 months. There was a statistically significant difference in BCVA between baseline and the end of the follow-up (pConclusions Application of ICGA-guided standard PDT, with a laser spot size of minimum diameter, on the site of active leakage seems to be effective and safe in a long-term follow-up period, presenting improvement in BCVA, decrease in CRT, and low rate of recurrence. |
| Databáze: | OpenAIRE |
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