The protective effects of rutaecarpine on gastric mucosa injury in rats
| Autor: | Hui Qing Zhu, Jin Song Ding, Pan-Yue Deng, Shensi Shen, Chang Ping Hu, Yuan-Jian Li, Li Wang, Gui Shan Tan |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pharmaceutical Science Pharmacology Calcitonin gene-related peptide Ulcer index Analytical Chemistry Evodia Indole Alkaloids Rats Sprague-Dawley chemistry.chemical_compound Alkaloids Drug Discovery medicine Gastric mucosa Animals Stomach Ulcer Aspirin Plant Extracts Stomach Organic Chemistry Rutaecarpine Anti-Ulcer Agents digestive system diseases Rats Disease Models Animal medicine.anatomical_structure Complementary and alternative medicine chemistry Capsaicin Gastric Mucosa Quinazolines Molecular Medicine Gastric acid Female Capsazepine Phytotherapy |
| Zdroj: | Planta medica. 71(5) |
| ISSN: | 0032-0943 |
| Popis: | Previous investigations have shown that calcitonin gene-related peptide (CGRP) protects gastric mucosa against injury induced by acetylsalicylic acid (ASA) and that rutaecarpine activates vanilloid receptors to evoke CGRP release. In the present study, we examined the protective effects of rutaecarpine on gastric mucosa injury, and explored whether the protective effects of rutaecarpine are related to stimulation of endogenous CGRP release via activating vanilloid receptors in rats. In an ASA-induced ulceration model, gastric mucosal ulcer index, pH value of gastric juice and plasma concentrations of CGRP were determined. ASA significantly increased the gastric mucosal ulcer index and the back-diffusion of H+ through the mucosa. Rutaecarpine at the doses of 100 or 300 microg/kg (i.v.), and 300 or 600 microg/kg (intragastric, i.g.) reduced the ulcer index and back-diffusion of H+, which was abolished by pretreatment with capsaicin (50 mg/kg, s.c.) or capsazepine (3 mg/kg, i.v.), a competitive vanilloid receptor antagonist. Rutaecarpine significantly increased the plasma concentration of CGRP, which was also abolished by capsazepine. In a stress-induced ulceration model, rutaecarpine reduced gastric mucosal damages, which was abolished by capsazepine (5 mg/kg, i.p.). These results suggest that rutaecarpine protects the gastric mucosa against injury induced by ASA and stress, and that the gastroprotective effect of rutaecarpine is related to a stimulation of endogenous CGRP release via activation of the vanilloid receptor. |
| Databáze: | OpenAIRE |
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