Competing risk nomogram to predict cancer‑specific survival in esophageal cancer during the intensity‑modulated radiation therapy era: A single institute analysis
| Autor: | Weixiang Qi, Shengguang Zhao, Jiayi Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine medicine esophageal cancer Receiver operating characteristic tumor length business.industry Area under the curve Articles Esophageal cancer Nomogram medicine.disease Primary tumor Confidence interval Radiation therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort competing risk nomogram prognosis Radiology intensity-modulated radiation therapy business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2020.11448 |
| Popis: | The present study aimed to investigate the probability of cancer-associated mortality of patients with esophageal cancer undergoing intensity-modulated radiation therapy (IMRT), and to establish a competing risk nomogram to predict the esophageal cancer-specific survival (EC-SS) of these patients. A total of 213 patients with EC who underwent IMRT between January 2014 and May 2017 were selected to establish nomograms according to Fine and Gray's competing risk analysis. Predictive accuracy and discriminative ability of the model were determined using the concordance index (C-index), calibration curves and the area under receiver operating characteristic curves. Decision tree analysis was also constructed for patient grouping. With a median follow-up of 19 months (range, 3–50), the 2-year EC-specific mortality (EC-SM) and the non-esophageal cancer specific mortality (NEC-SM) of the cohort were 35.4 and 3.51%, respectively. Furthermore, an elevated 2-year EC-SM was observed in patients with tumor length ≥4.5 cm compared with patients with tumor length |
| Databáze: | OpenAIRE |
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