Dorsolateral prefrontal cortex and hippocampus sustain impulsivity and aggressiveness in borderline personality disorder
| Autor: | Francesca Gambini, M. De Bona, Paolo Brambilla, Giorgio d'Allio, G. De Vidovich, Elisa Marraffini, Miriam Isola, Mariaelvina Sala, Matteo Lazzaretti, Federico Zappoli, Francesco Barale, Gianluca Rambaldelli, Niccolò Morandotti, Edgardo Caverzasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male hippocampus media_common.quotation_subject Poison control Prefrontal Cortex impulsivity Grey matter Hippocampal formation Impulsivity behavioral disciplines and activities Borderline Personality Disorder mental disorders medicine Humans Borderline personality disorder media_common Psychiatric Status Rating Scales Psychological Tests dorsolateral prefrontal cortex aggressiveness medicine.disease Magnetic Resonance Imaging Dorsolateral prefrontal cortex Aggression Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Case-Control Studies Impulsive Behavior Impulse (psychology) Female medicine.symptom Psychology Psychopathology Clinical psychology |
| Popis: | Background Borderline Personality Disorder (BPD) patients are characterized by increased levels of aggressivity and reduction of impulse control, which are behavioural dimensions mainly sustained by hippocampus and dorsolateral prefrontal cortex (DLPFC). In this study we aimed at investigating whether hippocampus and DLPFC anatomy may sustain impulsive and aggressive behaviours in BPD. Methods Fifteen DSM-IV BPD patients (11 females, 4 males) and fifteen 1:1 matched healthy controls (11 females, 4 males) were studied with a 1.5T magnetic resonance imaging (MRI) and underwent a psychopathological assessment in order to measure the severity of aggressive and impulsive traits. Results Right hippocampal volumes were significantly reduced in BPD patients compared to healthy subjects (p = 0.027), particularly in those with a history of childhood abuse (p = 0.01). Moreover, in patients but not in controls, right hippocampal volumes significantly inversely correlated with aggressiveness and DLPFC grey matter volumes significantly inversely associated with impulsiveness (p Conclusions Our results provide evidence that hippocampus and DLPFC play a separate and unique role in sustaining the control of impulse and aggressive behaviours in BPD patients. |
| Databáze: | OpenAIRE |
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