Free Triiodothyronine Is Associated With Hepatic Steatosis and Liver Stiffness in Euthyroid Chinese Adults With Non-Alcoholic Fatty Liver Disease
| Autor: | Wen Guo, Nianzhen Xu, Wenfang Zhu, Pei Qin, Qun Zhang, Jing Lu, Xiaona Li, Juan Wu, Qing-qing Diao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty China Endocrinology Diabetes and Metabolism Thyrotropin Thyroid Function Tests Gastroenterology Severity of Illness Index Diseases of the endocrine glands. Clinical endocrinology Endocrinology Fibrosis Internal medicine Medicine Humans Euthyroid Risk factor Ultrasonography Original Research business.industry hepatic steatosis Fatty liver euthyroidism non-alcoholic fatty liver disease free triiodothyronine Middle Aged medicine.disease RC648-665 Thyroxine liver stiffness Liver Triiodothyronine Female Thyroid function Steatosis Transient elastography business Hormone |
| Zdroj: | Frontiers in Endocrinology, Vol 12 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | ObjectiveThe association between non-alcoholic fatty liver disease (NAFLD) and thyroid hormones in euthyroid subjects is unclear. We investigated the relationship between thyroid function and the severity of hepatic steatosis and liver fibrosis in a large cohort of euthyroid Chinese adults.MethodsA total of 3496 participants were enrolled. Liver ultrasonography was used to define the presence of NAFLD (n=2172) or the absence of NAFLD (n=1324). Anthropometric and biochemical measurements were made and thyroid function parameters including free triiodothyronine (FT3), free thyroxine (FT4), thyroid‐stimulating hormone (TSH) were measured. The severity of hepatic steatosis and liver stiffness was assessed by transient elastography.ResultsLevels of FT3 were significantly higher in the severe NAFLD group and moderate NAFLD group than in the mild NAFLD group (5.18 ± 0.58 vs 5.11 ± 0.57 vs 4.98 ± 0.60 pmol/L, Pvs 5.29 ± 0.48 vs 5.20 ± 0.50 pmol/L, Pvs 63.1% vs 73.3%, Pvs 18.6% vs 20.8%, PConclusionsThere are positive associations of FT3 levels with the severity of hepatic steatosis and the presence of liver fibrosis in NAFLD with euthyroidism. |
| Databáze: | OpenAIRE |
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