The etiology of premature rupture of the membranes
| Autor: | Kim Brady, William Polzin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Fetus
Pregnancy Fetal Membranes Premature Rupture business.industry Cell Obstetrics and Gynecology Interleukin Prom Prenatal care Bacterial Infections Bioinformatics medicine.disease Embryonic and Fetal Development medicine.anatomical_structure Chorioamnionitis Risk Factors medicine Collagenase Etiology Humans Female business medicine.drug |
| Zdroj: | Clinical obstetrics and gynecology. 41(4) |
| ISSN: | 0009-9201 |
| Popis: | The etiology of PROM is multifactorial. It is clear that maternal enzymes, maturational and mechanical forces, chorionicamniotic membrane phospholipid content, collagen disruption, amniotic cell cytokines induced by fetal signals, and bacterial phospholipases and collagenases all play major and interrelated roles. It is also clear that the production of oxytocic prostaglandins is a major, if not exclusive, common pathway leading to PROM and preterm delivery. The increasing awareness of the fetal role, i.e., fetal interleukins, fetal polymorphonuclear leukocytes and type V collagenase, make this area of research ripe for further investigation. The complex host defense mechanisms and biologic variability make any universal treatment impossible. Even with a specific etiology determined, the reduced availability of pharmacologic interventions for the fetal compartment portend suboptimal success. Therefore, it appears that continued research and aggressive measures to optimize the quality and availability of prenatal care are the best foci of our efforts. |
| Databáze: | OpenAIRE |
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