Antioxidants as Therapy in the Newborn: Some Words of Caution
| Autor: | A. Keith Tanswell, Robert P. Jankov, Anna Negus |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant medicine.medical_treatment Disease Bioinformatics Antioxidants Infant Newborn Diseases Pathogenesis Humans Medicine Neonatology Neonatal Disorder chemistry.chemical_classification Reactive oxygen species business.industry Mechanism (biology) Infant Newborn chemistry Pediatrics Perinatology and Child Health Reactive Oxygen Species business Oxidation-Reduction Cell Division Infant Premature Target organ |
| Zdroj: | Pediatric Research. 50:681-687 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-200112000-00009 |
| Popis: | Reactive oxygen and nitrogen species are considered to play a major role in the pathogenesis of a wide range of human disorders. This may be a particularly important pathogenetic mechanism in the newborn nursery. The phrase "oxygen radical disease of prematurity" has been coined to collectively describe a wide range of neonatal disorders based on the belief that premature newborns are deficient in antioxidant defenses at a time when they are subjected to acute and chronic oxidant stresses. This belief has led to a number of clinical trials of antioxidant therapies being undertaken in neonatal patients. The realization that reactive oxygen species play a critical role in neonatal illnesses has only recently been paralleled by an increased understanding of their physiologic roles. A major concern is that effective scavenging of reactive oxygen species, to attenuate their toxic effects, will also inhibit essential cellular functions such as growth in potential target organs such as lung, brain, intestine, and retina. |
| Databáze: | OpenAIRE |
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