Area-specific modification of acetylcholinesterase activity following 3-mercaptopropionic acid-induced seizures
| Autor: | Georgina Rodríguez de Lores Arnaiz, Patricia G. Schneider, Elena Girardi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Hippocampus Striatum chemistry.chemical_compound Reference Values Seizures Internal medicine medicine Animals Rats Wistar 3-Mercaptopropionic Acid Molecular Biology Butyrylcholinesterase Cerebral Cortex Chemistry General Neuroscience Brain Acetylcholinesterase Corpus Striatum Rats medicine.anatomical_structure Endocrinology nervous system Organ Specificity Cerebral cortex Convulsant Cholinergic Neurology (clinical) |
| Zdroj: | Molecular and Chemical Neuropathology. 21:13-22 |
| ISSN: | 1044-7393 |
| DOI: | 10.1007/bf03160081 |
| Popis: | Acetylcholinesterase activity (AChE) was assayed in rat CNS membrane fractions after administration of the convulsant 3-mercaptopropionic acid (150 mg/kg, ip). In comparison with saline-injected controls, total AChE activity decreased 12–20% in striatum and cerebellum during seizure and postseizure but failed, to change in cerebral cortex. Specific AChE activity, assayed in the presence of 10−4 M ethopropazine (a butyrylcholinesterase inhibitor) decreased 15–25% in striatum and cerebellum, increased 20–45% in hippocampus, but remained unchanged in cerebral cortex. Saline injection alone increased AChE activity in striatum (68%) and cerebellum (36%) but failed to modify enzyme activity in hippocampus and cerebral cortex. To conclude, AChE sensitivity to convulsant, and saline administration is tissue-specific and not restricted to cholinergic areas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink