Unraveling the complex nature of prostate cancer stem cells
| Autor: | G I Gallicano, A Stuart, N Fingland, S Mobley, Kara Foshay, A Miera |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Neoplasms Hormone-Dependent Population Biology Models Biological Prostate cancer Prostate Internal medicine Genetics medicine Animals Humans Epigenetics education Cytoskeleton education.field_of_study Cluster of differentiation Prostatic Neoplasms General Medicine medicine.disease medicine.anatomical_structure Neoplastic Stem Cells Cancer research Signal transduction Stem cell |
| Zdroj: | Cancer Biomarkers. 3:233-244 |
| ISSN: | 1875-8592 1574-0153 |
| Popis: | The identification of distinct prostate cancer stem cell biomarkers is necessary as researchers attempt to isolate, characterize, and therapeutically target these tumor initiating cells. However, in reading the current literature it is frequently difficult to discern which biomarkers and cellular characteristics identify prostate cancer stem cells as opposed to the general population of prostate cancer cells or normal prostate stem cells. Within this review, we address this issue by dissecting out the cell surface markers, adhesion and cytoskeletal proteins, signaling pathways, epigenetic modifications, and the effects of androgens that are specific to and help to define the prostate cancer stem cell. |
| Databáze: | OpenAIRE |
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