Distribution of hepatitis C virus genotypes among hemodialysis patients in Tehran—a multicenter study
| Autor: | Nazanin Aghel, Seyed Mohammadmehdi Hosseini-Moghaddam, Hossein Keyvani, Hossein Kasiri, Seyed Moayed Alavian, Seyed Mohammad Kazemeyni, Abbas Basiri |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Urban Population Hepatitis C virus Hepacivirus medicine.medical_treatment Population Iran medicine.disease_cause Shahid Flaviviridae Species Specificity Renal Dialysis Risk Factors Virology Genotype Humans Medicine education Genotyping education.field_of_study biology business.industry Middle Aged biology.organism_classification Hepatitis C Cross-Sectional Studies Hemodialysis Units Hospital Infectious Diseases Kidney Failure Chronic RNA Viral Female Hemodialysis business Polymorphism Restriction Fragment Length |
| Zdroj: | Journal of Medical Virology. 78:569-573 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.20577 |
| Popis: | Urology and Nephrology Research Centre (UNRC), Shahid Beheshti University of Medical Science (SBUMS),Tehran, IranHepatitisCvirushassubstantialheterogeneityofgenotypes throughout the world. The aim of thisstudy was to determine the frequency of HCVgenotypes, risk factors and clinical implicationsin cases of hemodialysis living in Tehran. A totalof155patientstreatedbyhemodialysis,whohadbeen identified to be anti-HCV positive at 45medical centers in Tehran, were enrolled. Geno-typing was using restriction fragment lengthpolymorphism(RFLP)onHCV-RNApositivesam-ples. HCV-RNA was detected in 66 (42.6%) pati-ents. Genotyping of HCV-RNA positive serumsamples demonstrated that subtypes 3a and 1awerepredominantaccountingfor30.3and28.8%,respectively.Thedistributionof otherHCVgeno-types showed genotype 1b, 18.2%; genotype 4,16.7%; mixed genotypes 1a and 1b, 3%; andgenotype3b,3%.Genotype2wasnotdetectedinthis study. Statistically significant differenceswere identified between HCV infected and non-HCVinfectedpatientsregardinghistoryofhemo-dialysis unit changes more than two times(P¼0.01), and history of hemodialysis for morethan 20 years (P¼0.02). However, blood transfu-sion,meandurationofhemodialysistherapyandthe history of solid organ transplantation did notdiffer between these two groups. This studyindicates that the dominant HCV genotypesamong patients treated by hemodialysis livingin Tehran were 3a and 1a, and consideringprevious reports from the general population,genotype 4 was strongly associated with hemo-dialysis. The duration of treatment by hemo-dialysis and, in turn, more hemodialysis unitchanges will lead to more frequent HCV infec-tions. Liss, Inc. J. Med. Virol. 78:569–573,2006. |
| Databáze: | OpenAIRE |
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