Comparison of the effects of subconjunctival and topical anti-VEGF therapy (bevacizumab) on experimental corneal neovascularization
| Autor: | Ozgul Altintas, Ozdemir Ozdemir, Levent Altintaş, Nurşen Yüksel, Cigdem Akdag, Berna Özkan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
genetic structures medicine.medical_treatment Disease models animal Neovascularization Cornea Random Allocation lcsh:Ophthalmology Injeções Medicine Saline Ratos Anti vegf Corneal Diseases Antibodies Monoclonal General Medicine Inibidores de angiogênese/administração & dosagem Bevacizumab Vascular endothelial growth factor A Anesthesia Modelos animais de doenças Cauterization Corneal neovascularization/chemically induced medicine.symptom Injections Intraocular medicine.drug medicine.medical_specialty Corneal diseases Antibodies Monoclonal Humanized Injections Angiogenesis inhibitors/administration and dosage Ophthalmology Animals Corneal Neovascularization Neovascularização da córnea/induzido quimicamente Rats Wistar business.industry Animais medicine.disease eye diseases Rats Disease Models Animal lcsh:RE1-994 Fator A de crescimento do endotélio vascular Corneal neovascularization Histopathology sense organs business Doenças da córnea |
| Zdroj: | Arquivos Brasileiros de Oftalmologia v.77 n.4 2014 Arquivos brasileiros de oftalmologia Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO Arquivos Brasileiros de Oftalmologia, Volume: 77, Issue: 4, Pages: 209-213, Published: AUG 2014 Arquivos Brasileiros de Oftalmologia, Vol 77, Iss 4, Pp 209-213 (2014) Arquivos Brasileiros de Oftalmologia, Vol 77, Iss 4, Pp 209-213 |
| ISSN: | 1678-2925 |
| Popis: | Purpose: To compare the effects of bevacizumab applied either subconjunctivally or topically, in a rat model of corneal neovascularization induced by alkali burn. Methods: The right corneas of 24 Wistar-Albino rats were cauterized with silver nitrate sticks. The rats were divided randomly and equally into three groups: no treatment control (n=8), subconjunctival bevacizumab treatment (n=8), and topical bevacizumab treatment (n=8). Immediately following cauterization, the subconjunctival group was treated with a 0.05 ml (1.25 mg) bevacizumab subconjunctival injection. The topical group was treated with 10 mg/ml bevacizumab twice daily, and the control group received subconjunctival saline injections twice daily. The burn stimulus and neovascularization scores were evaluated using a technique previously described by Mahoney and Waterbury. Digital photographs were obtained before the eyes were enucleated and corneal sections were then analyzed by histopathology. Results: The mean burn stimulus score was 1.86 ± 0.6 and there was no statistical difference between the groups (p=0.730). The mean neovascularization scores in the subconjunctival and topical bevacizumab groups were statistically lower than the control group (p |
| Databáze: | OpenAIRE |
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