Intraocular and Systemic Pharmacokinetics of Triamcinolone Acetonide after a Single 40-mg Posterior Subtenon Application
| Autor: | Lingyun Cheng, Li-jun Shen, Yong-sheng You, Jia Qu, Shumao Sun, Yiqi Chen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Triamcinolone acetonide Tenon Capsule medicine.drug_class Absorption (skin) Triamcinolone Acetonide Systemic circulation Aqueous Humor Young Adult Pharmacokinetics Tandem Mass Spectrometry medicine Humans Distribution (pharmacology) Prospective Studies Glucocorticoids Chromatography High Pressure Liquid Aged Aged 80 and over Aqueous solution Chromatography business.industry Middle Aged Acetonide Vitreous Body Ophthalmology Anesthesia Corticosteroid Female business Half-Life medicine.drug |
| Zdroj: | Ophthalmology. 117:2365-2371 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/j.ophtha.2010.03.033 |
| Popis: | Purpose To characterize the pharmacokinetics of triamcinolone acetonide (TA) in aqueous, vitreous, and systemic circulation after a single subtenon injection. Design Prospective interventional case series. Participants Thirty-six patients (36 eyes) who received a single posterior subtenon injection of TA (40 mg in 0.4 ml). Methods Aqueous, vitreous, and blood samples were obtained at 1-hour, 1-day, 3-day, 5-day, 10-day, 14-day, 21-day, and 28-day time points after the posterior subtenon TA injection. At each time point, there were 3 to 6 eyes (patients). The concentrations of TA in the aqueous, vitreous, and plasma were analyzed using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Main Outcome Measures Triamcinolone acetonide concentration in the samples was measured, and pharmacokinetic parameters were calculated. Results The TA concentration-time profile in aqueous consisted of a fast distribution phase during the first 24 hours and a slow elimination phase thereafter. In contrast, the TA concentration-time profile in vitreous consisted of an absorption phase during the first 24 hours followed by a slow elimination phase. The TA in plasma followed a mono-exponential elimination during the study course. The TA concentration peak time for aqueous and plasma was at 1 hour and 24 hours, for vitreous after subtenon injection. The terminal elimination half-life in aqueous, vitreous, and plasma was 11.8, 17.1, and 25 days, respectively. The integral of the area under the concentration time curve (AUC 0-∞ ) was 862 ng/day/ml for aqueous, 1262 ng/day/ml for vitreous, and 17.4 ng/day/ml for plasma. The total TA exposure to vitreous was 46% more than total TA exposure to the aqueous. The TA concentration in vitreous was 70- to 98-fold higher than that in plasma. Conclusions Posterior subtenon TA application can provide a sustained high local ocular TA level while also resulting in a very low systemic TA level, which may be well below the normal glucocorticoid level in humans. Financial Disclosure(s) The authors have no proprietary or commercial interest in any materials discussed in this article. |
| Databáze: | OpenAIRE |
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