Novel Organ Perfusion and Preservation Strategies in Controlled Donation After Circulatory Death in Pancreas and Kidney Transplantation
| Autor: | J. Branchereau, A.E. Ogbemudia, S. Le Bas-Bernardet, T. Prudhomme, J. Rigaud, G. Karam, G. Blancho, B. Mesnard |
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| Přispěvatelé: | Nuffield Department of Surgical Sciences [Oxford, UK], University of Oxford, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Le Bihan, Sylvie |
| Rok vydání: | 2021 |
| Předmět: |
MESH: organ preservation
Transplantation MESH: kidney transplantation MESH: tissue donors [SDV]Life Sciences [q-bio] Organ Preservation MESH: perfusion Kidney Transplantation Tissue Donors [SDV] Life Sciences [q-bio] Perfusion surgical procedures operative MESH: pancreas Humans MESH: humans Surgery Pancreas |
| Zdroj: | Transplantation Proceedings Transplantation Proceedings, 2022, 54 (1), pp.77-79. ⟨10.1016/j.transproceed.2021.09.059⟩ |
| ISSN: | 1873-2623 0041-1345 |
| DOI: | 10.1016/j.transproceed.2021.09.059⟩ |
| Popis: | International audience; Background. Kidney and pancreatic transplants from controlled donation after circulatory death donors are vulnerable to ischemia-reperfusion injuries. In this context of transplant shortage, there is a need to optimize the function of these transplants and to develop novel perfusion and preservation strategies in controlled donation after circulatory death in kidney and pancreatic transplants. In Situ Perfusion and Preservation Strategies. In situ regional normothermic perfusion improves the outcome of kidney transplants from controlled donation after circulatory death and provides equivalent results for the kidney from brain-dead donors. In situ regional normothermic perfusion is under investigation for pancreatic transplants. Ex Situ Perfusion and Preservation Strategies. Perfusion on hypothermic machine perfusion is highly recommended for the kidney from controlled donation after cardiac death. Hypothermic oxygenated perfusion machine decreases the rate of graft rejection and graft failure in kidney transplantation. Ex situ normothermic perfusion is an easy way to assess renal function. In the future, kidney transplants could benefit from drug therapy during ex situ normothermic perfusion. In pancreas transplantation, hypothermic machine perfusion and ex situ normothermic perfusion present encouraging results in preclinical studies. |
| Databáze: | OpenAIRE |
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