Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre
| Autor: | Jie Gao, Yudi Zhang, Zhijian Xiao, Dan Wu, Naibo Hu, Wenyu Cai, Y Zhang, Sirui Ren, Zefeng Xu, Bing Li, Huijun Huang, Gang Huang, Jinqin Liu, Lijuan Pan, Lihong Shi, Peihong Zhang, Shiqiang Qu, Jiaxi Zhou, Tiejun Qin, Changlu Xu, Meng Jiao, Robert Peter Gale |
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| Rok vydání: | 2020 |
| Předmět: |
Ineffective erythropoiesis
Premature aging Oncology Adult Male medicine.medical_specialty Adolescent Erythroblasts Decitabine Apoptosis medicine.disease_cause lcsh:RC254-282 Article Young Adult Erythroid Cells Bone Marrow Internal medicine hemic and lymphatic diseases medicine Humans Clinical significance Erythropoiesis Progenitor cell Cellular Senescence Aged Aged 80 and over Univariate analysis business.industry Myelodysplastic syndromes Hematopoietic Stem Cell Transplantation Hematology Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis Myelodysplastic Syndromes Biomarker (medicine) Female business K562 Cells Myelodysplastic syndrome medicine.drug |
| Zdroj: | Blood Cancer Journal Blood Cancer Journal, Vol 10, Iss 8, Pp 1-12 (2020) |
| ISSN: | 2044-5385 |
| Popis: | The underlying mechanisms and clinical significance of ineffective erythropoiesis in myelodysplastic syndromes (MDS) remain to be fully defined. We conducted the ex vivo erythroid differentiation of megakaryocytic-erythroid progenitors (MEPs) from MDS patients and discovered that patient-derived erythroblasts exhibit precocity and premature aging phenotypes, partially by inducing the pro-aging genes, like ERCC1. Absolute reticulocyte count (ARC) was chosen as a biomarker to evaluate the severity of ineffective erythropoiesis in 776 MDS patients. We found that patients with severe ineffective erythropoiesis displaying lower ARC (9/L), were more likely to harbor complex karyotypes and high-risk somatic mutations (p p p p = 0.525). Our study revealed that ineffective erythropoiesis in MDS may be partially caused by premature aging and apoptosis during erythroid differentiation. MDS patients with severe ineffective erythropoiesis have significant shorter OS treated with immunosuppressive or hypo-methylating agents, but may benefit from Allo-HSCT. |
| Databáze: | OpenAIRE |
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