Enhanced gastric retention and drug release via development of novel floating microspheres based on Eudragit E100 and polycaprolactone: synthesis and in vitro evaluation
| Autor: | Nazar Mohammad Ranjha, Shahid Nawaz, Umar Farooq, Malik Salman Haider, Eshwa Dar, Samiullah Khan, Muhammad Muzamil Khan, Ahmad Nawaz |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Materials science Polymers and Plastics Scanning electron microscope General Chemical Engineering Metronidazole Benzoate media_common.quotation_subject 02 engineering and technology 030226 pharmacology & pharmacy Polyvinyl alcohol Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine metronidazole benzoate Eudragit E 100 Materials Chemistry Fourier transform infrared spectroscopy media_common chemistry.chemical_classification Chromatography oil in water (o/w) method Articles General Chemistry Polymer Floating microspheres 021001 nanoscience & nanotechnology In vitro lcsh:TP1080-1185 lcsh:Polymers and polymer manufacture chemistry gastric retention and drug release Polycaprolactone 0210 nano-technology |
| Zdroj: | Designed Monomers and Polymers Designed Monomers and Polymers, Vol 20, Iss 1, Pp 419-433 (2017) |
| ISSN: | 1568-5551 |
| Popis: | Eudragit E 100 and polycaprolactone (PCL) floating microspheres for enhanced gastric retention and drug release were successfully prepared by oil in water solvent evaporation method. Metronidazole benzoate, an anti-protozoal drug, was used as a model drug. Polyvinyl alcohol was used as an emulsifier. The prepared microspheres were observed for % recovery, % degree of hydration, % water uptake, % drug loading, % buoyancy and % drug release. The physico-chemical properties of the microspheres were studied by calculating encapsulation efficiency of microspheres and drug release kinetics. Drug release characteristics of microspheres were studied in simulated gastric fluid and simulated intestinal fluid i.e., at pH 1.2 and 7.4 respectively. Fourier transform infrared spectroscopy was used to reveal the chemical interaction between drug and polymers. Scanning electron microscopy was conducted to study the morphology of the synthesized microspheres. |
| Databáze: | OpenAIRE |
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