| Autor: |
C Hagemann, N Neuhaus, M Dahlmann, A F Kessler, D Kobelt, P Herrmann, M Eyrich, B Freitag, T Linsenmann, C M Monoranu, R Ernestus, M Löhr, U Stein |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
BACKGROUND: IDH1-mutation and MGMT-promoter methylation are established prognostic markers in glioblastoma multiforme (GBM); however, invasive procedures are needed to obtain the required tumor tissue. Metastasis-associated in colon cancer-1 (MACC1) has been established as a prognostic plasma marker for several solid cancer entities. Here, we evaluated circulating MACC1 transcripts for prediction of clinical outcome and therapy response in GBM. MATERIAL AND METHODS: Plasma samples were collected from 45 GBM patients (31 IDH1 wildtype (wt), 5 IDH1R132H, 9 unspecified) before surgery. The patients’ clinical course was followed for 24 months. Samples from 15 healthy volunteers served as controls. MACC1-transcript levels, determined by qRT-PCR, were correlated with patient overall survival (OS) and clinical data of known prognostic significance. Cut-off values for Kaplan-Meier analyses were determined by ROC calculations. Cluster analyses were performed. RESULTS: MACC1 transcripts were higher in patients plasma compared to healthy controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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