Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding
| Autor: | David Berron, Hartmut Schütze, Anne Maass, Kay H. Brodersen, Hans-Jochen Heinze, Klaas E. Stephan, Claus Tempelmann, Arturo Cardenas-Blanco, Oliver Speck, Emrah Düzel, Andrew P. Yonelinas |
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| Přispěvatelé: | University of Zurich, Maass, Anne |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male 1.2 Psychological and socioeconomic processes 1.1 Normal biological development and functioning physiology [Hippocampus] General Physics and Astronomy Hippocampus 610 Medicine & health 1600 General Chemistry General Biochemistry Genetics and Molecular Biology Article 170 Ethics Young Adult 1300 General Biochemistry Genetics and Molecular Biology Underpinning research Memory Neural Pathways Entorhinal Cortex Humans 10237 Institute of Biomedical Engineering Recognition memory diagnostic imaging [Hippocampus] Multidisciplinary Recall Long-term memory Chemistry Dentate gyrus Novelty Neurosciences Episodic encoding General Chemistry Entorhinal cortex Magnetic Resonance Imaging 3100 General Physics and Astronomy Radiography Mental Health nervous system Neurological Female ddc:500 diagnostic imaging [Entorhinal Cortex] Neuroscience physiology [Entorhinal Cortex] |
| Zdroj: | Nature Communications Nature communications, vol 5, iss 1 Nature Communications, 5 Nature Communications 5(1), 5547 (2014). doi:10.1038/ncomms6547 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms6547 |
| Popis: | The ability to form long-term memories for novel events depends on information processing within the hippocampus (HC) and entorhinal cortex (EC). The HC–EC circuitry shows a quantitative segregation of anatomical directionality into different neuronal layers. Whereas superficial EC layers mainly project to dentate gyrus (DG), CA3 and apical CA1 layers, HC output is primarily sent from pyramidal CA1 layers and subiculum to deep EC layers. Here we utilize this directionality information by measuring encoding activity within HC/EC subregions with 7 T high resolution functional magnetic resonance imaging (fMRI). Multivariate Bayes decoding within HC/EC subregions shows that processing of novel information most strongly engages the input structures (superficial EC and DG/CA2–3), whereas subsequent memory is more dependent on activation of output regions (deep EC and pyramidal CA1). This suggests that while novelty processing is strongly related to HC–EC input pathways, the memory fate of a novel stimulus depends more on HC–EC output. Nature Communications, 5 ISSN:2041-1723 |
| Databáze: | OpenAIRE |
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