Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description
| Autor: | Esteban Porrini, Maria del Carmen García Baute, Ana Rodríguez-Rodríguez, Alberto Dominguez-Rodriguez, Lourdes Pérez Tamajón, Raúl Morales Febles, Natalia Negrín Mena, Alejandra Alvarez Gonzalez, Ana González Rinne, Federico Gonzalez Rinne, Laura Díaz Martín, Domingo Marrero Miranda, Armando Torres Ramírez, Aurelio Rodríguez Hernández, Cristian Acosta Sørensen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male Pediatrics medicine.medical_specialty Population Prediabetic State Diabetes mellitus Medicine Aerobic exercise Humans Prediabetes Risk factor education Exercise education.field_of_study business.industry Incidence (epidemiology) Middle Aged medicine.disease Kidney Transplantation Transplantation Feasibility Studies Female business Anaerobic exercise |
| Zdroj: | Nephron. 145(1) |
| ISSN: | 2235-3186 |
| Popis: | Background: Post-transplant diabetes mellitus (PTDM) is a frequent and severe complication after renal transplantation. In fact, PTDM is a risk factor for both infection and cardiovascular diseases. The prevalence and incidence of PTDM have a bimodal evolution: early (up to 3 months) and late PTDM (beyond 12 months). The majority of late PTDM occurs in subjects with prediabetes after transplantation. So, treating patients with prediabetes, a potentially reversible condition, might help preventing PTDM. In the general population, exercise prevents the evolution from prediabetes to diabetes. However, in renal transplantation, not enough evidence is available in this field. Objectives: We designed an exploratory analysis to evaluate the feasibility of exercise to reverse prediabetes as a first step in the design of a trial to prevent PTDM. Methods: Only patients with prediabetes beyond 12 months after transplantation with capacity to perform exercise will be included. Prediabetes will be diagnosed based on fasting glucose levels and oral glucose tolerance tests (OGTTs). Patients will be treated with a stepped training intervention, starting with aerobic exercise training (brisk walking, swimming, and cycling) 5 times per week and 30 min/day. Aerobic exercise training will be gradually increased to 60 min/day or eventually combined with anaerobic exercise training in case of persistent prediabetes. The reversibility/persistence of prediabetes will be measured with fasting glucose and OGTTs every 3 months. This study will last for 12 months. |
| Databáze: | OpenAIRE |
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