Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration
| Autor: | Anika M. Jonker, Joop G.C. Wolke, Jan C. M. van Hest, John A. Jansen, Sander C.G. Leeuwenburgh, Rosa P. Félix Lanao |
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| Rok vydání: | 2013 |
| Předmět: |
Bone Regeneration
Biocompatibility Biomedical Engineering Bioengineering macromolecular substances Bio-Organic Chemistry Biochemistry Biomaterials Food and drug administration chemistry.chemical_compound Polylactic Acid-Polyglycolic Acid Copolymer Absorbable Implants Animals Humans Lactic Acid Bone regeneration Review Articles Glycolic acid Tissue Scaffolds Chemistry technology industry and agriculture Biodegradation Tissue engineering and pathology [NCMLS 3] Synthetic polymer Lactic acid PLGA Chemical engineering Bone Substitutes Polyglycolic Acid Biomedical engineering |
| Zdroj: | Tissue Engineering. Part B: Reviews, 19, 4, pp. 380-90 Tissue Engineering. Part B: Reviews, 19, 380-90 |
| ISSN: | 1937-3376 1937-3368 |
| Popis: | Item does not contain fulltext Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro- and nanospheres to meet various clinical requirements. |
| Databáze: | OpenAIRE |
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