The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule
| Autor: | Birgit Brenner, Florian Lang, Ursula Koppenhoefer, Erich Gulbins |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Ceramide
T-Lymphocytes CD40 Ligand Biophysics chemical and pharmacologic phenomena Biology Ceramides Biochemistry Cell Line Substrate Specificity Mice chemistry.chemical_compound stomatognathic system immune system diseases Structural Biology T lymphocyte Tumor Cells Cultured Genetics Animals Molecule CD40 Antigens Tyrosine kinase Molecular Biology Membrane Glycoproteins CD40 hemic and immune systems Cell Biology Ligand (biochemistry) Sphingomyelins Cell biology Enzyme Activation Kinetics stomatognathic diseases Sphingomyelin Phosphodiesterase chemistry biology.protein Neutral sphingomyelinase Sphingomyelin Protein Kinases Function (biology) Signal Transduction |
| Zdroj: | FEBS Letters. 414:444-448 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(97)01035-1 |
| Popis: | Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4]. Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingomyelinase correlating with a consumption of sphingomyelin and a release of ceramide. Activation of the neutral sphingomyelinase by the CD40L seems to involve a novel signalling cascade since it is independent of CD40L induced protein kinase activation or association of the neutral sphingomyelinase with the CD40L. |
| Databáze: | OpenAIRE |
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