Transforming growth factor beta signaling: The master sculptor of fingers
| Autor: | Carlos I. Lorda-Diez, Juan M. Hurle, Juan A. Montero, Cristina Duarte-Olivenza |
|---|---|
| Přispěvatelé: | Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
animal structures Morphogenesis Context (language use) Chick Embryo Social Care 03 medical and health sciences Mice 0302 clinical medicine Transforming Growth Factor beta Animals Scoping Review Protocol biology Mechanism (biology) Embryogenesis Social Support Embryo Extremities Transforming growth factor beta Chondrogenesis Cell biology Health Care 030104 developmental biology Social Networks Bone Morphogenetic Proteins embryonic structures biology.protein 030217 neurology & neurosurgery Function (biology) Social Network Analysis Developmental Biology Signal Transduction |
| Zdroj: | Dev Dyn . 2022 Jan;251(1):125-136 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) |
| Popis: | Transforming growth factor beta (TGFβ) constitutes a large and evolutionarily conserved superfamily of secreted factors that play essential roles in embryonic development, cancer, tissue regeneration and human degenerative pathology. Studies of this signaling cascade in the regulation of cellular and tissue changes in the three-dimensional context of a developing embryo have notably advanced in the understanding of the action mechanism of these growth factors. In this review, we address the role of TGFβ signaling in the developing limb, focusing on its essential function in the morphogenesis of the autopod. As we discuss in this work, modern mouse genetic experiments together with more classical embryological approaches in chick embryos, provided very valuable information concerning the role of TGFβ and Activin family members in the morphogenesis of the digits of tetrapods, including the formation of phalanxes, digital tendons and interphalangeal joints. We emphasize the importance of the Activin and TGFβ proteins as digit inducing factors and their critical interaction with the BMP signaling to sculpt the hand and foot morphology. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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