Regulatory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques
| Autor: | Jacob George, Diego Medvedovsky, Shmuel Schwartzenberg, Ari Shamiss, Gideon Charach, Arnon Afek, Michael Jonas |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Acute coronary syndrome Myocardial Infarction Inflammation Coronary Artery Disease Coronary Angiography medicine.disease_cause T-Lymphocytes Regulatory Asymptomatic Internal medicine medicine Humans Myocardial infarction Israel Coronary atherosclerosis Aged Aged 80 and over Chi-Square Distribution Rupture Spontaneous Adiponectin business.industry Stem Cells Case-control study Endothelial Cells Middle Aged medicine.disease Coronary Vessels Vulnerable plaque Plaque Atherosclerotic Interleukin-10 Case-Control Studies Disease Progression Cardiology Female Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 222:519-523 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2012.03.016 |
| Popis: | Despite having a similar large extent of atherosclerotic coronary affliction, some patients suffer of recurrent cardiac events, whereas others remain asymptomatic.We hypothesized the existence of a systemic "signature" that could distinguish "vulnerable" patients with preexisting coronary atherosclerosis from those having similar risk factors and atheromatous burden, but no history of clinically evident plaque rupture/erosion.Twenty three patients who had at least two prior myocardial infarctions ("vulnerable group") were matched in respect to their background and coronary atherosclerosis extent with twenty one patients without a history of previous myocardial infarction who underwent routine coronary angiography before valvular surgery. We studied a panel of cytokines, antibodies and hormones including IL-6, IL-10, IL-12, antibodies to β2 glycoprotein I (β2GPI), antibodies to oxidized-LDL, adiponectin and resistin, along with levels of circulating EPCs and Tregs.A significantly higher level of Treg cells was present in the control (73.4%±4) than in the "vulnerable patient" group (62.2%±10.7), p0.001. IL-10 level was also significantly higher in the control than in the vulnerable patients (2.6±1.2 pg/ml versus 0.9±0.1 pg/ml respectively, p=0.03). There was no significant difference in the circulating levels of the other cytokines, hormones or EPCs between the two groups.Regulatory T cells and serum IL-10 may discriminate "vulnerable" versus stable patients and may have a protective role against plaque rupture in patients with coronary atherosclerosis. |
| Databáze: | OpenAIRE |
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