Resting‐state connectome‐based support‐vector‐machine predictive modeling of internet gaming disorder

Autor: Ziliang Wang, Marc N. Potenza, Kun-Ru Song, Yuan-Wei Yao, Shan-Shan Ma, Jing Lan, Gaolang Gong, Lu-Lu Wu, Cui-Cui Xia, Linyuan Deng, Lu Liu, Jin-Tao Zhang, Xiaoyi Fang
Rok vydání: 2020
Předmět:
Zdroj: Addiction Biology. 26
ISSN: 1369-1600
1355-6215
DOI: 10.1111/adb.12969
Popis: Internet gaming disorder (IGD), a worldwide mental health issue, has been widely studied using neuroimaging techniques during the last decade. Although dysfunctions in resting-state functional connectivity have been reported in IGD, mapping relationships from abnormal connectivity patterns to behavioral measures have not been fully investigated. Connectome-based predictive modeling (CPM)-a recently developed machine-learning approach-has been used to examine potential neural mechanisms in addictions and other psychiatric disorders. To identify the resting-state connections associated with IGD, we modified the CPM approach by replacing its core learning algorithm with a support vector machine. Resting-state functional magnetic resonance imaging (fMRI) data were acquired in 72 individuals with IGD and 41 healthy comparison participants. The modified CPM was conducted with respect to classification and regression. A comparison of whole-brain and network-based analyses showed that the default-mode network (DMN) is the most informative network in predicting IGD both in classification (individual identification accuracy = 78.76%) and regression (correspondence between predicted and actual psychometric scale score: r = 0.44, P < 0.001). To facilitate the characterization of the aberrant resting-state activity in the DMN, the identified networks have been mapped into a three-subsystem division of the DMN. Results suggest that individual differences in DMN function at rest could advance our understanding of IGD and variability in disorder etiology and intervention outcomes.
Databáze: OpenAIRE