The Azaindole Framework in the Design of Kinase Inhibitors
| Autor: | Pascal Bonnet, Karen Plé, Jean-Yves Mérour, Frédéric Buron, Sylvain Routier |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Indoles
Pharmaceutical Science Review 010402 general chemistry 01 natural sciences Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Animals Humans kinase inhibitors structural analysis Physical and Theoretical Chemistry Protein Kinase Inhibitors Aza Compounds 010405 organic chemistry Chemistry Drug discovery Kinase Organic Chemistry kinase binding mode Combinatorial chemistry 0104 chemical sciences 3. Good health Chemistry (miscellaneous) Drug Design Molecular Medicine azaindoles |
| Zdroj: | Molecules Molecules, Vol 19, Iss 12, Pp 19935-19979 (2014) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules191219935 |
| Popis: | This review article illustrates the growing use of azaindole derivatives as kinase inhibitors and their contribution to drug discovery and innovation. The different protein kinases which have served as targets and the known molecules which have emerged from medicinal chemistry and Fragment-Based Drug Discovery (FBDD) programs are presented. The various synthetic routes used to access these compounds and the chemical pathways leading to their synthesis are also discussed. An analysis of their mode of binding based on X-ray crystallography data gives structural insights for the design of more potent and selective inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|