Struvite urolithiasis in a B6C3F1 mouse
| Autor: | R. C. Renlund, N. J. Barsoum, Zbigniew W. Wojcinski, Graham S. Smith |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Struvite urolithiasis
Male medicine.medical_specialty Struvite Urology Magnesium Compounds Urine Phosphates Rodent Diseases chemistry.chemical_compound Mice X-Ray Diffraction Cystitis medicine Scalding Animals Magnesium Mice Inbred C3H General Veterinary business.industry Transitional epithelium Hyperplasia medicine.disease Mice Inbred C57BL Subacute cystitis medicine.anatomical_structure chemistry Animal Science and Zoology Female Urinary Calculi Bladder stones business Crystallization |
| Zdroj: | Laboratory animals. 26(4) |
| ISSN: | 0023-6772 |
| Popis: | In a 2 year carcinogenicity bioassay using B6C3F1 mice, one male mouse developed clinical signs near termination of the study, comprising skin sores around the prepuce, penile prolapse and urine scalding. The predominant finding at necropsy was a markedly distended urinary bladder filled with numerous crystallized particles. Microscopically, there was subacute cystitis with marked hyperplasia of the transitional epithelium. X-ray diffraction analysis of the crystals showed a diffraction pattern characteristic of struvite (ammonium magnesium phosphate). The implications of the spontaneous occurrence of bladder stones in rodents on long-term toxicology studies are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|