A Case Report of Primary Nasal Natural Killer (NK)/T-Cell Lymphoma in an African American Patient Presenting with Hemophagocytic Syndrome
| Autor: | Thomas Toltaku, Bowei Tan, Jen C. Wang, Cherif Abdelmalek, Vladimir Gotlieb, James E O'Donnell, Rashid Chaudhry |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Herpesvirus 4 Human medicine.medical_treatment Neutropenia Lymphohistiocytosis Hemophagocytic 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Biopsy Biomarkers Tumor medicine Humans T-cell lymphoma medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin Combination chemotherapy Chemoradiotherapy Articles General Medicine Middle Aged medicine.disease Lymphoma Black or African American Lymphoma Extranodal NK-T-Cell Radiation therapy Treatment Outcome medicine.anatomical_structure Epstein-Barr Virus Nuclear Antigens 030220 oncology & carcinogenesis Immunology Bone marrow Hemophagocytosis business 030215 immunology |
| Zdroj: | The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| DOI: | 10.12659/ajcr.900995 |
| Popis: | Patient: Male, 55 Final Diagnosis: Primary NK-T cell lymphoma • nasal type Symptoms: Fever • nasal bleeding • nasal mass • weight loss Medication: — Clinical Procedure: Chemotherapy×2 cycles • radiation therap Specialty: Oncology Objective: Rare disease Background: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL) is generally an aggressive and rare non-Hodgkin lymphoma. It is most common in East Asians, Native Americans, and South Americans, but is rarely reported in blacks. Case Report: A 55-year-old African American male born in Grenada presented with a left nostril mass with facial swelling and biopsy subsequently confirmed a diagnosis of extranodal NK/T-cell lymphoma, nasal type (ENKTCL). Immunochemistry was positive for CD2, cytoplasmic CD3, CD7, CD 43, CD 56, granzyme B, and TIA-1. In situ hybridization was positive for Epstein-Barr virus encoded ribonucleic acid (EBERs). Bone marrow aspiration did not show lymphoma involvement. The patient had progressive neutropenia upon presentation, with further investigations showing hepatomegaly, hyperferritinemia, and hemophagocytosis in the bone marrow. We reached a diagnosis of hemophagocytic syndrome. He was treated with a high-dose combination chemotherapy and radiation therapy; the neutropenia improved significantly with steroids as treatment for immune activation in the setting of hemophagocytic syndrome. Conclusions: To the best of our knowledge, this is the only second report of extranodal NK/T-cell lymphoma, nasal type in a black patient, and it raises the awareness of early recognition of rare manifestations of NK/T-cell lymphoma such as hemophagocytic syndrome. |
| Databáze: | OpenAIRE |
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