Geographic and Temporal Analysis of Folate-Sensitive Fetal Malformations
| Autor: | Richard K. Silver, Cindy J. Nowinski, Michelle Kambich, MacGregor Sn, Trent E. J. Gordon, Elizabeth A. Leeth |
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| Rok vydání: | 2003 |
| Předmět: |
Temporal clustering
Heart Defects Congenital Pediatrics medicine.medical_specialty Reproductive medicine Folic Acid Deficiency Congenital Abnormalities Pregnancy Epidemiology medicine Cluster Analysis Humans Neural Tube Defects Urinary Tract Obstructive uropathy Gastroschisis Fetus business.industry Anomaly (natural sciences) Infant Newborn Obstetrics and Gynecology Targeted interventions medicine.disease Female Illinois business |
| Zdroj: | Journal of the Society for Gynecologic Investigation. 10:298-301 |
| ISSN: | 1071-5576 |
| DOI: | 10.1016/s1071-55760300086-8 |
| Popis: | OBJECTIVE: To identify potential geographic and temporal clustering of folate-sensitive fetal malformations as a prelude to a targeted preconception curriculum in folic acid supplementation. METHODS: Our comprehensive prenatal anomaly database was queried to select fetal malformations presumed to be sensitive to preconception folate insufficiency. Evidence of geographic clustering was evaluated by distribution of individual cases using zip codes of maternal residence. Potential temporal clustering of anomalies was sought by tabulating the frequency of each anomaly category during 5 consecutive 2-year intervals between 1992 and 2001. RESULTS: Over a 10-year period, approximately 2000 fetal anomalies were identified, of which 400 (20%) were considered potentially folaic sensitive. We found geographic clustering of ventral wall defects as well as obstructive uropathy by zip code analysis. Significant increases in the frequencies of cardiac defects (P |
| Databáze: | OpenAIRE |
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