FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs

Autor: Weidong Li, R. Arlen Price, Hongyu Zhao
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Adult
Genetic Markers
Linkage disequilibrium
medicine.medical_specialty
lcsh:Internal medicine
endocrine system diseases
Adolescent
lcsh:QH426-470
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Biology
FTO gene
Polymorphism
Single Nucleotide
Linkage Disequilibrium
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Chromosome regions
medicine
Genetics
Humans
Genetics(clinical)
lcsh:RC31-1245
Genetics (clinical)
030304 developmental biology
Aged
2. Zero hunger
0303 health sciences
Cytogenetics
Proteins
nutritional and metabolic diseases
pathological conditions
signs and symptoms
Middle Aged
medicine.disease
Obesity
Obesity
Morbid
lcsh:Genetics
Genetic marker
Case-Control Studies
Female
Body mass index
Research Article
Zdroj: BMC Medical Genetics, Vol 9, Iss 1, p 4 (2008)
BMC Medical Genetics
ISSN: 1471-2350
Popis: Background FTO is a gene located in chromosome region 16q12.2. Recently two studies have found associations of several single nucleotide polymorphisms (SNPs) in FTO with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, and rs9939609. Methods We examined these three SNPs in 583 extremely obese women with current BMI greater than 35 kg/m2 and lifetime BMI greater than 40 kg/m2, and 544 controls who were currently normal weight (BMI2) and had never been overweight during their lifetimes. Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10-9). The strongest association was with rs1421085 (p = 3.04 × 10-10, OR = 1.75, CI = 1.47–2.08). A subset of 99 cases had extremely discordant sisters with BMI2. The discordant sisters differed in allele and genotype frequencies in parallel with the overall case and control sample. The strongest association was with rs17817449 (z = 3.57, p = 3.6 × 10-4). Conclusion These results suggest common variability in FTO is associated with increased obesity risk or resistance and may in part account for differences between closely related individuals.
Databáze: OpenAIRE
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