Effects of coasting on the outcome of intracytoplasmic sperm injection-embryo transfer cycles

Autor: Onur Bilgin, Kaan Bozkurt, Sait Yücebilgin, Dilek Ozer, Erdal Aktan, Nedim Karadadaş
Rok vydání: 2004
Předmět:
Zdroj: The AustralianNew Zealand journal of obstetricsgynaecology. 44(4)
ISSN: 0004-8666
Popis: Objectives: To determine the effects of ‘coasting’ on the outcome of controlled ovarian hyperstimulation (COH) and intracytoplasmic sperm injection–embryo transfer (ICSI–ET). Design: Retrospective study. Setting: IVF Centre, Ozel Ege Tup Bebek Merkezi, Izmir, Turkey. Sample: Twenty-six coasted and 52 non-coasted COH and ICSI–ET patients were enrolled in this retrospective study. Methods: Coasted patients were enrolled consecutively during the study period, and two non-coasted controls were selected from our database for each coasted patient. Coasting was decided when serum oestradiol level was ≥4000 pg/mL. Groups were compared using χ2 and Mann–Whitney U-tests for statistical analysis. Main Outcome Measures: Number of oocytes collected, metaphase II (MII) oocytes and cleaving embryos, the fertilisation rate and clinical pregnancy rate were the main outcome measures. Results: Number of oocytes collected, number of MII oocytes, number of cleaving embryos, fertilisation rate and clinical pregnancy rate for the coasted and non-coasted groups were 15.5 ± 5.2 and 14.0 ± 7.1, 9.7 ± 4.8 and 9.3 ± 3.9, 6.8 ± 3.9 and 5.8 ± 3.1, 0.85 ± 0.18 and 0.78 ± 0.18, 13/26 and 24/52, respectively; these differences were not statistically significant. None of the patients in the coasted group were hospitalised for signs or findings of severe ovarian hyperstimulation syndrome. Conclusions: Coasting does not adversely affect the number and the function of mature oocytes and the clinical pregnancy rate.
Databáze: OpenAIRE
Externí odkaz: