Nucleolar organizer regions in human oral verrucous carcinoma and adjacent lining epithelium
Autor: | Andrea Monti Hughes, Maria E. Itoiz, Analía Méndez, Amanda E. Schwint |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Histology Normal oral mucosa Biology Epithelium 03 medical and health sciences 0302 clinical medicine Paraffin section medicine Biomarkers Tumor Nucleolus Organizer Region Humans Carcinoma Verrucous Oral mucosa Aged 030102 biochemistry & molecular biology Verrucous carcinoma Significant difference General Medicine Middle Aged medicine.disease Nucleolar Organizer Region Gene Expression Regulation Neoplastic stomatognathic diseases Medical Laboratory Technology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Mouth Neoplasms Nucleolus organizer region |
Zdroj: | Biotechnichistochemistry : official publication of the Biological Stain Commission. 95(7) |
ISSN: | 1473-7760 |
Popis: | The epithelium adjacent to an oral squamous cell carcinoma is at risk of undergoing precancerous changes. Even after such changes occur, however, the adjacent epithelium remains histologically similar to normal mucosa. We investigated five argyrophilic nucleolar organizer region (AgNOR)-related features in samples of oral verrucous carcinoma (VeCa) and their corresponding adjacent lining epithelium (adj. VeCa). Morphometric characteristics of AgNORs in oral adj. VeCa and oral VeCa were compared to normal mucosa epithelium, squamous cell carcinoma and oral mucosa epithelium adjacent to squamous cell carcinoma findings that we published earlier. Although adj. VeCa and normal oral mucosa were histologically similar, total AgNOR volume differentiated adj. VeCa from normal oral mucosa, but revealed no significant difference between VeCa and adj. VeCa. Total AgNOR volume/nuclear volume discriminated VeCa from adj. VeCa and normal oral mucosa. Certain AgNOR parameters provide a complementary tool for discriminating VeCa from adj. VeCa and normal oral mucosa, and also for detecting incipient malignant changes in epithelium adjacent to VeCa. Use of the AgNOR technique is cost-effective, because it can be performed on paraffin sections. |
Databáze: | OpenAIRE |
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