Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes
| Autor: | OI Okoye, P U Agu, Nkiru C. Azubike, DC Nwachukwu, NZ Nwachukwu, E Aneke, L F O Obika, Anthonius A. Eze |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Water-Electrolyte Imbalance Urology Nigeria Urine electrolytes Blood Pressure 030204 cardiovascular system & hematology law.invention Clinical study Electrolytes 03 medical and health sciences 0302 clinical medicine Hydrochlorothiazide Randomized controlled trial law Internal medicine medicine Humans Single-Blind Method In patient 030212 general & internal medicine Amlodipine Antihypertensive Agents Original Research Dose-Response Relationship Drug business.industry Blood Pressure Determination General Medicine Middle Aged Treatment Outcome Blood pressure Endocrinology Hypertension Female Once daily business medicine.drug |
| Zdroj: | Malawi Medical Journal Malawi Medical Journal; Vol 29, No 2 (2017); 108-112 |
| ISSN: | 1995-7262 |
| DOI: | 10.4314/mmj.v29i2.6 |
| Popis: | Background: Amlodipine and hydrochlorothiazide (HCTZ) are commonly prescribed in Nigeria either as a monotherapy or in combination with other drugs. The present study was designed to investigate the antihypertensive efficacy of monotherapy with amlodipine or HCTZ and their effects on electrolyte profile in patients with mild to moderate hypertension. Methods: A single-blind randomized clinical study was used; fifty patients newly diagnosed with mild to moderate hypertension (aged 33 to 60 years) were recruited and divided into two groups: amlodipine or hydrochlorothiazide each comprising of 25 subjects. The subjects received 5mg of amlodipine or 25mg of hydrochlorothiazide in their respective group once daily for 4 weeks. Blood pressure, serum and urine electrolytes were measured at baseline and weekly throughout the experiment. Results: At the end of follow up, amlodipine reduced systolic and diastolic blood pressure significantly more (p |
| Databáze: | OpenAIRE |
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