Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery
| Autor: | Mario I. Ortiz, Eduardo Fernández-Martínez, Raúl Monroy-Maya, Gerardo Reyes-Garcia, Alexis F. Garza-Hernández, Lourdes Carrillo-Alarcón, Marisela Soto-Rios, Héctor A. Ponce-Monter |
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| Rok vydání: | 2011 |
| Předmět: |
lcsh:R5-920
medicine.medical_specialty Article Subject Visual analogue scale business.industry Pyridoxine Lower limb Surgery Clinical trial B vitamins stomatognathic diseases Anesthesiology and Pain Medicine Diclofenac Anesthesia medicine Clinical Study Neurology (clinical) Cyanocobalamin lcsh:Medicine (General) business Acute pain medicine.drug |
| Zdroj: | Pain Research and Treatment Pain Research and Treatment, Vol 2012 (2012) |
| ISSN: | 2090-1550 |
| Popis: | The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine, and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours presurgery and twenty-four hours postsurgical. One hundred twenty-two patients completed the study. The subjects' assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect. The novelty of this paper consists in that diclofenac and diclofenac plus B vitamins were useful for treatment of acute pain originated by lower-limb fracture and surgery. |
| Databáze: | OpenAIRE |
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