Hepatic steatosis as an independent risk factor for severe disease in patients with COVID ‐19: A computed tomography study

Autor: Robert Escarria‐Panesso, Eric Kimura-Hayama, Gabriela Hernández-Molina, Andres Palomar‐Lever, Gustavo Barraza, Melissa Echeverri‐Bolaños, José Halabe-Cherem, Jorge Padua‐Barrios, Talia Nila Chargoy‐Loustaunau, Julieta Galicia‐Alba
Rok vydání: 2020
Předmět:
Zdroj: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
JGH Open
ISSN: 2397-9070
DOI: 10.1002/jgh3.12395
Popis: Background and Aim Hepatic steatosis (HS) is associated with diabetes, hypertension, and obesity, comorbidities recently related to COVID‐19 severity. Here, we assessed if tomographic HS is also a risk factor for severe COVID‐19 pneumonia. Methods We included 213 patients with a positive real time polymerase chain reaction (RT‐PCR) test and chest computed tomography (CT) from an out‐hospital facility and a hospital. We obtained information on demographics; weight; height; smoking history; diabetes; hypertension; and cardiovascular, lung, and renal disease. Two radiologists scored the CO‐RADs system (COVID‐19 Reporting and Data System) (1 = normal, 2 = inconsistent, 3–4 = indeterminate, and 5 = typical findings) and the chest CT severity index (≥20 of 40 was considered severe disease). They evaluated the liver‐to‐spleen ratio (CTL/S) and defined tomographic steatosis as a CTL/S index ≤0.9. We used descriptive statistics, χ2 and t student tests, logistic regression, and reported odds ratio (OR) with 95% confidence interval (CI). Results Of the patients, 61% were men, with a mean age of 51.2 years, 48.3% were CO‐RADs 1 and 51.7% CO‐RADs 2–5. Severe tomographic disease was present in 103 patients (48.4%), all CO‐RADs 5. This group was older; mostly men; and with a higher prevalence of obesity, hypertension, diabetes, and HS (69.9 vs 29%). On multivariate analysis, age (OR 1.058, 95% CI 1.03–1.086, P
Hepatic steatosis is an independent risk factor for chest computed tomography ?(CT)?severe ?COVID‐19? infection (odds ratio 4.9, 95% confidence interval 2.4–?9.7, P
Databáze: OpenAIRE
Externí odkaz: