| Autor: |
Nikolaos Smyrnis, Felicia Iftene, Olivera Vuković, Henry K. Karlsson, Jan Hilbig, Dan J. Stein, Marc De Hert, C. Bredicean, Ion Papava, Sanja Vodopic, Jean-Michel Azorin, Athanasios Douzenis, Maija Walta, Hasan Karadağ, Petra Furstova, Filip Spaniel, Klaudia Domowicz, Anuja Bendre, María Paz García-Portilla, Gamze Erzin, Erik Thys, Valentina Corigliano, Paweł Wójciak, Anastasia Konsta, Amresh Shrivastava, Anca-Livia Panfil, Dora Vajda, Elmars Rancans, Martien Wampers, Lidija Injac Stevovic, Leticia García-Álvarez, Anita Juhasz, Oluremi Oladele, Xenofon Atmatzidis, Alvydas Navickas, Ioannis Michopoulos, Pavel Knytl, Ida S. Haussleiter, Trayana Hristova, Rajiv Tandon, Dusica Lecic-Tosevski, Maria Luísa Figueira, Fleur M. Howells, Laurynas Bukelskis, Daria Smirnova, Leonidas Mantonakis, Olga Izmailova, Joana Crawford, Justine Bouniard, Panagiotis Ferentinos, Vincent Russell, Oluyomi Esan, Julie Montant, Tobias Wiklund, Tiina From, Luchezar Hranov, Roumen Milev, Georg Juckel, Nikolaos K. Fountoulakis, Michael Berk, Janusz K. Rybakowski, Ioannis Nimatoudis, Elena Dragioti, Cyril Höschl, Julio Bobes, Zsófia Nemes, Anna Comparelli, Bojana Pejuskovic, Olivia M Dean, Konstantinos N. Fountoulakis, Avinash De Sousa, Loukas Athanasiadis, Daniil Aptalidis, Ludgero Linhares, Henk Temmingh, Raimo K. R. Salokangas, Antonis T. Theofilidis, John L. Waddington, Xenia Gonda, Christopher Osunbote, Siegfried Kasper, Maurizio Pompili |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
CNS spectrums |
| ISSN: |
1092-8529 |
| Popis: |
BackgroundThe aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia.MethodsTwenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 ± 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia; the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects.ResultsThere was a 3-year later age at onset for females (P P P P = .001). No significant effects were found concerning duration of illness.DiscussionOur results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative samples. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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