Cardiovascular response to acute hypoxemia in adult rats hypoxemic neonatally
| Autor: | T. Matsuoka, Charles V. Rohlicek, C. Saiki |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Physiology Hemodynamics Blood Pressure Cardiovascular System Hypoxemia Rats Sprague-Dawley Heart Rate Physiology (medical) Heart rate Animals Medicine Hypoxia business.industry Central venous pressure Stroke Volume Hypoxia (medical) Rats Blood pressure medicine.anatomical_structure Animals Newborn Anesthesia Vascular resistance Arterial blood Vascular Resistance medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Research. 53:263-270 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(01)00475-8 |
| Popis: | Objective: To determine the effects of chronic hypoxemia neonatally on the cardiovascular response to acute hypoxemia in adulthood. Methods: Experiments were conducted on adult rats (82±2 days) which had been made chronically hypoxemic (hypobaric hypoxia equivalent to FiO2=0.14) during the first ten days of life but raised in room air (Neonatally Hypoxemia) as well as on adult rats never previously hypoxemic (Control). The animals were instrumented with catheters in the right common carotid artery and superior vena cava for measurements of mean systemic arterial pressure (MAP), central venous pressure, heart rate (HR), arterial blood gases, and arterial as well as mixed venous O2 saturation. Oxygen consumption (![Graphic][1] O2) was measured allowing calculation of cardiac index (CI), stroke volume index (SVI) and systemic vascular resistance index (SVRI). The rats were made acutely hypoxemic by exposure to FiO2=0.10 for 20 min. Results: HR increased and MAP decreased to similar extents in both groups during acute hypoxemia. However, SVI and CI increased significantly ( P |
| Databáze: | OpenAIRE |
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