Elevated plasma histamine concentrations in surgery: causes and clinical significance

Autor: W. Seidel, G. Häfner, P. Dormann, H. Hamelmann, Wilfried Lorenz, A. Doenicke, R. Tauber, H. J. Reimann, A. Schmal, R. Uhlig, G. Mann
Rok vydání: 1974
Předmět:
Tachycardia
Male
Swine
Plasma Substitutes
610 Medizin
Blood Pressure
Histamine Release
Gastric Juice/secretion
chemistry.chemical_compound
Postoperative Complications
Drug Discovery
Fluorometry
Genetics (clinical)
Postoperative Complications/physiopathology
Whole blood
ddc:610
Gastric Juice
Stomach
Histamine Release/drug effects
General Medicine
Haplorhini
Middle Aged
Pathophysiology
Atropine
Anesthesia
Surgical Procedures
Operative
Molecular Medicine
Premedication
Female
medicine.symptom
Plasma Substitutes/therapeutic use
Histamine
medicine.drug
Adult
medicine.medical_specialty
Manometry
Hemorrhage
Dogs
Anesthetics/pharmacology
medicine
Animals
Humans
Clinical significance
Hemorrhage/etiology
Anesthetics
business.industry
Hemodynamics
Histamine/blood
Surgery
chemistry
Stomach/physiology
business
DOI: 10.5283/epub.21872
Popis: Histamine concentrations in plasma, whole blood and various tissues of human subjects, monkeys, pigs and dogs were determined by fluorometric methods before, during and after surgical operations. Following intraabdominal surgery in 6 of 22 patients elevated plasma histamine levels were found several hours after the end of operation. Some of the causes of histamine release in surgery were found to be premedication by atropine, intravenously administered anaesthetics, infusion of plasma substitutes and manipulation on the gut. Acute blood losses were without effect on the plasma histamine levels. Clinical symptoms and pathophysiological reactions, such as tachycardia, hypotension, increased gastric secretion and anaphylactoid reactions could be related to the release of histamine in some circumstances.
Databáze: OpenAIRE
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