Acute Kidney Injury With Ventricular Assist Device Placement: National Estimates of Trends and Outcomes
Autor: | Savitri E. Fedson, Sankar D. Navaneethan, Ajith Nair, Anita Deswal, Wolfgang C. Winkelmayer, Carl P. Walther, Jeffrey A. Morgan, Faisal H. Cheema, Jingbo Niu |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Surgical stress Adolescent medicine.medical_treatment 030232 urology & nephrology urologic and male genital diseases 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Ventricular Assist Device Placement Humans Decompensation 030212 general & internal medicine Hospital Mortality Hospital Costs Dialysis Aged Retrospective Studies Heart Failure urogenital system business.industry Incidence Acute kidney injury Acute Kidney Injury Middle Aged medicine.disease Prognosis female genital diseases and pregnancy complications United States Hospitalization Renal Replacement Therapy Survival Rate Nephrology Heart failure Emergency medicine Female Heart-Assist Devices business Kidney disease Cohort study Follow-Up Studies |
Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 74(5) |
ISSN: | 1523-6838 |
Popis: | Rationale & Objective Ventricular assist devices (VADs) are used for end-stage heart failure not amenable to medical therapy. Acute kidney injury (AKI) in this setting is common due to heart failure decompensation, surgical stress, and other factors. Little is known about national trends in AKI diagnosis and AKI requiring dialysis (AKI-D) and associated outcomes with VAD implantation. We investigated national estimates and trends for diagnosed AKI, AKI-D, and associated patient and resource utilization outcomes in hospitalizations in which implantable VADs were placed. Study Design Cohort study of 20% stratified sample of US hospitalizations. Setting & Participants Patients who underwent implantable VAD placement in 2006 to 2015. Exposure No AKI diagnosis, AKI without dialysis, AKI-D. Outcomes In-hospital mortality, length of stay, estimated hospitalization costs. Analytical Approach Multivariate logistic and linear regression using survey design methods to account for stratification, clustering, and weighting. Results An estimated 24,140 implantable VADs were placed, increasing from 853 in 2006 to 3,945 in 2015. AKI was diagnosed in 56.1% of hospitalizations and AKI-D occurred in 6.5%. AKI diagnosis increased from 44.0% in 2006 to 2007 to 61.7% in 2014 to 2015; AKI-D declined from 9.3% in 2006 to 2007 to 5.2% in 2014 to 2015. Mortality declined in all AKI categories but this varied by category: those with AKI-D had the smallest decline. Adjusted hospitalization costs were 19.1% higher in those with diagnosed AKI and 39.6% higher in those with AKI-D, compared to no AKI. Limitations Administrative data; timing of AKI with respect to VAD implantation cannot be determined; limited pre-existing chronic kidney disease ascertainment; discharge weights not derived for subpopulation of interest. Conclusions A decreasing proportion of patients undergoing VAD implantation experience AKI-D, but mortality among these patients remains high. AKI diagnosis with VAD implantation is increasing, possibly reflecting changes in AKI surveillance, awareness, and coding. |
Databáze: | OpenAIRE |
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