Impaired executive function exacerbates neural markers of posttraumatic stress disorder
| Autor: | Joseph DeGutis, Audreyana Jagger-Rickels, Catherine Fortier, Anna Stumps, Hannah Park, Regina E. McGlinchey, William P. Milberg, Jennifer R. Fonda, Agnieszka Zuberer, Francesca C. Fortenbaugh, Michael Esterman, David Rothlein |
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| Rok vydání: | 2021 |
| Předmět: |
Resting state fMRI
business.industry 05 social sciences Cognition Amygdala Article 050105 experimental psychology Dorsolateral prefrontal cortex 03 medical and health sciences Psychiatry and Mental health Posttraumatic stress 0302 clinical medicine medicine.anatomical_structure Control network medicine Biomarker (medicine) 0501 psychology and cognitive sciences business Neurocognitive Neuroscience 030217 neurology & neurosurgery Applied Psychology |
| Zdroj: | Psychol Med |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291721000842 |
| Popis: | BackgroundA major obstacle in understanding and treating posttraumatic stress disorder (PTSD) is its clinical and neurobiological heterogeneity. To address this barrier, the field has become increasingly interested in identifying subtypes of PTSD based on dysfunction in neural networks alongside cognitive impairments that may underlie the development and maintenance of symptoms. The current study aimed to determine if subtypes of PTSD, based on normative-based cognitive dysfunction across multiple domains, have unique neural network signatures.MethodsIn a sample of 271 veterans (90% male) that completed both neuropsychological testing and resting-state fMRI, two complementary, whole-brain functional connectivity analyses explored the link between brain functioning, PTSD symptoms, and cognition.ResultsAt the network level, PTSD symptom severity was associated with reduced negative coupling between the limbic network (LN) and frontal-parietal control network (FPCN), driven specifically by the dorsolateral prefrontal cortex and amygdala Hubs of Dysfunction. Further, this relationship was uniquely moderated by executive function (EF). Specifically, those with PTSD and impaired EF had the strongest marker of LN-FPCN dysregulation, while those with above-average EF did not exhibit PTSD-related dysregulation of these networks.ConclusionThese results suggest that poor executive functioning, alongside LN-FPCN dysregulation, may represent a neurocognitive subtype of PTSD. |
| Databáze: | OpenAIRE |
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