Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice
| Autor: | Nariaki Fujimoto, M Nishizaki, Hiromitsu Watanabe, Shuneki Shoji, Ken Kuramoto, Osamu Katoh, S Kido, Y Ishimura, T Ogiu, Shitau Hirata, K Shiraki |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Neoplasms Radiation-Induced Ratón Ovary Biology medicine.disease_cause Kidney Mice Adrenal Glands Testis medicine Animals Heavy Ions Irradiation Crosses Genetic Ovarian Neoplasms Mice Inbred C3H Sex Characteristics Oncogene Liver Neoplasms Cancer General Medicine Organ Size medicine.disease Heavy ion irradiation Proximal point Mice Inbred C57BL medicine.anatomical_structure Oncology Female Carcinogenesis Spleen |
| Zdroj: | Oncology reports. 5(6) |
| ISSN: | 1021-335X |
| Popis: | Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males. |
| Databáze: | OpenAIRE |
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