Neurologic complications in dengue virus infection: A prospective cohort study
| Autor: | Amita Jain, Hardeep Singh Malhotra, Praveen Kumar Sharma, Anit Parihar, Maneesh Kumar Singh, Ritesh Sahu, Rajesh Verma, Ravindra Kumar Garg |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent India Dengue virus Hematocrit medicine.disease_cause Dengue fever Dengue Young Adult Central Nervous System Diseases Internal medicine medicine Humans Prospective Studies Young adult Child Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test business.industry Incidence (epidemiology) Infant Peripheral Nervous System Diseases Middle Aged Prognosis medicine.disease Rash Surgery Child Preschool Neurology (clinical) medicine.symptom business Cohort study |
| Zdroj: | Neurology. 83:1601-1609 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000000935 |
| Popis: | This study aimed to evaluate the incidence and clinical spectrum of neurologic complications, predictors of central and peripheral nervous system involvement, and their outcome in patients with dengue virus infection (DENV).To determine the extent of neurologic complications, we used a hospital-based prospective cohort study design, which included laboratory-confirmed cases of dengue and follow-up for 3 months. We also analyzed clinical and laboratory data to assess predictors of neurologic involvement.The study included enrollment of 486 cases. Two were lost to follow-up and excluded. Forty-five patients developed neurologic complications. Of these, 28 patients had CNS and 17 had peripheral nervous system (PNS) involvement, representing an incidence rate for neurologic complications of 9.26%. Significant predictors of CNS involvement were higher mean body temperature (p = 0.012), elevated hematocrit (p = 0.009), low platelet count (p = 0.021), and liver dysfunction (p0.001). Predictors of PNS involvement were higher mean body temperature (p = 0.031), rash (p = 0.002), and elevated hematocrit (p0.001). The mortality rate was 4.5%. The remainder of the patients recovered.An increasingly wide spectrum and higher incidence of neurologic complications of DENV are reported. Clinical and laboratory parameters such as higher mean body temperature, rash, increases in hematocrit, thrombocytopenia, and liver dysfunction are independent predictors of neurologic complications. |
| Databáze: | OpenAIRE |
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