BiFACIAL ( Biomimetic Freestanding Anisotropic Catechol- Interfaces with Asymmetrically Layered) Films as Versatile Extracellular Matrix Substitutes
| Autor: | Yoojin Kim, Jae Hyung Jang, Byung Gee Im, Mira Cho, Minjae Do |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Catechols Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Extracellular matrix chemistry.chemical_compound Rheology Biomimetics Highly porous Animals General Materials Science Composite material Anisotropy Porosity Catechol Chitosan 021001 nanoscience & nanotechnology 0104 chemical sciences Extracellular Matrix chemistry Ionic strength 0210 nano-technology Porous medium |
| Zdroj: | ACS applied materialsinterfaces. 10(9) |
| ISSN: | 1944-8252 |
| Popis: | Biological naïve extracellular matrices (ECMs) exhibit anisotropic functions in their physical, chemical, and morphological properties. Representative examples include anisotropic skin layers or blood vessels simultaneously facing multiphasic environments. Here, anisotropically multifunctional structures called BiFACIAL ( biomimetic freestanding anisotropic catechol- interfaces with asymmetrically layered) films were developed simply by contacting two polysaccharide solutions of heparin-catechol (Hep-C) and chitosan-catechol (Chi-C). Such anisotropic characters were due to controlling catechol cross-linking by alkaline pH, resulting in a trimodular structure: a rigid yet porous Hep-C exterior, nonporous interfacial zone, and soft/highly porous Chi-C interior. The anisotropic features of each layer, including the porosity, rigidity, rheology, composition, and ionic strength, caused the BiFACIAL films to show spontaneously biased stimuli responses and differential behaviors against biological substances (e.g., blood plasma). The films could be created in situ in live animals and imitated the structural/functional aspects of the representative anisotropic tissues (e.g., skin and blood vessels), providing valuable ECM-like platforms for the creation of favorable environments or for tissue regeneration or disease treatment by effectively manipulating cellular behaviors. |
| Databáze: | OpenAIRE |
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