The possibility of using PlasmaDeepDive™ MRM panel in clinical diagnostics
| Autor: | A. Yu. Belyaev, N B Teryaeva, N. A. Petushkova, N.E. Moskaleva, V. G. Zgoda, Ekaterina V. Ilgisonis, Iu.V. Miroshnichenko |
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| Rok vydání: | 2015 |
| Předmět: |
Proteomics
Chromatography integumentary system Human blood Chemistry Quantitative proteomics Selected reaction monitoring Blood Proteins General Medicine Mass spectrometry Mass Spectrometry General Biochemistry Genetics and Molecular Biology Tandem Mass Spectrometry Human plasma Potential biomarkers Humans Quantitative analysis (chemistry) |
| Zdroj: | Biomeditsinskaya Khimiya. 61:272-278 |
| ISSN: | 2310-6905 2310-6972 |
| DOI: | 10.18097/pbmc20156102272 |
| Popis: | Concentrations of 46 proteins have been determined in human blood plasma using PlasmaDeepDive™ MRM Panel ("Biognosys AG", Switzerland). 18 of them were included into the group of proteins with higher concentrations, also identified by the shotgun proteomic analysis. Based on literature data it is concluded that the PlasmaDeepDive™ MRM Panel is applicable for studies of human plasma samples for potential biomarkers of various nervous system disorders.Opredeleny kontsentratsii 46 belkov plazmy krovi cheloveka metodom monitoringa dissotsiativnykh perekhodov s ispol'zovaniem mass-spektrometricheskoĭ paneli (MS-panel') PlasmaDeepDive™ (“Biognosys AG”, Shveĭtsariia) dlia kolichestvennogo analiza peptidov. 18 iz nikh, voshedshie v gruppu belkov s bolee vysokimi kontsentratsiiam, takzhe identifitsirovany metodom panoramnoĭ khromato-mass-spektrometrii. Na osnovanii dannykh literatury sdelan vyvod o vozmozhnosti ispol'zovaniia MS-paneli PlasmaDeepDive™ v issledovaniiakh, napravlennykh na opredelenie v plazme krovi cheloveka i otsenku klinicheskogo znacheniia potentsial'nykh markernykh belkov zabolevaniĭ nervnoĭ sistemy razlichnogo geneza. |
| Databáze: | OpenAIRE |
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