Na and Cl transport and short-circuit current in rabbit ileum
| Autor: | Giustina Danisi, Jehan-F. Desjeux, Peter F. Curran, Yuan-Heng Tai |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Physiology Biophysics Analytical chemistry Biological Transport Active Ileum In Vitro Techniques Models Biological Membrane Potentials Chlorides medicine Animals Transcellular Intestinal Mucosa Chemistry Significant difference Sodium Electric Conductivity Cell Biology Human physiology medicine.anatomical_structure Biochemistry Potassium Rabbits Low resistance Extracellular Space Na absorption Short circuit |
| Zdroj: | The Journal of membrane biology. 31(1-2) |
| ISSN: | 0022-2631 |
| Popis: | Na and Cl fluxes and short-circuit current (I sc) in rabbit ileum have been studied as a function of ionic concentrations in HCO3-free solutions. Both net Na flux (J net Na ) andI sc show similar saturation functions of [Na] at fixed [Cl]. They show no significant difference between zero and 112mm Na but at 140mm NaI sc is significantly greater than theJ net Na . Net Cl transport, secretion, is observed only at 140mm Na and is approximately equivalent to the difference between theI sc andJ net Na . The transcellular mucosa-to-serosa Na fluxes measured at 140 and 70mm Na do not differ significantly from the correspondingI sc. The net Cl flux varies with [Cl] at fixed [Na] whileI sc is virtually not affected by [Cl]. These results suggest that the absorptive Na transport process is electrogenic and responsible for theI sc and that the secretory fluxes of Na and Cl are coupled, require high [Na], vary with [Cl], and do not contribute toI sc. K-free solution abolishes theI sc after a prolonged lag. Finally, the effect of a low resistance shunt pathway on active Na absorption is examined with a four-compartment model. |
| Databáze: | OpenAIRE |
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