Exacerbation of Hypothyroidism Following Tumor Necrosis Factor-.ALPHA. Infusion
| Autor: | Yukihiro Nagai, Kenichi Kobayashi, Yukihiro Bando, Hisatsugu Miyakoshi, Hitoshi Yokoyama, Yasuhiko Ieki, Kenso Ohsawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Thyroid Hormones
endocrine system medicine.medical_specialty Skin Neoplasms endocrine system diseases Exacerbation Thyroid Gland Autoimmune thyroiditis Hypothyroidism Thyroid Hormone Treatment Antigen Internal medicine Internal Medicine medicine Humans Chronic thyroiditis HLA-D Antigens Tumor Necrosis Factor-alpha business.industry Thyroid General Medicine Middle Aged medicine.disease Lymphoma T-Cell Cutaneous Lymphoma Endocrinology medicine.anatomical_structure Female Tumor necrosis factor alpha business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Internal Medicine. 31:200-203 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.31.200 |
| Popis: | A46-year-old woman with chronic thyroiditis who had been receiving thyroid hormone treatment for 10yr developed severe hypothyroidism (FT4 0.37ng/dl, FT3 1.38pg/ml, TSH 151.00μU/ml) following tumor necrosis factor-α (TNF) infusion for the treatment of a complicated cutaneous T-cell lymphoma. Indirect immunofluorescence staining of thyroid follicular cells showed aberrant expression of HLA class II antigens. The mechanisms underlying the exacerbation of the hypothyroidism may be an augmentation of immunological processes in the thyroid and a direct action of TNF on the synthesis and secretion of thyroid hormone.(Internal Medicine 31 : 200-203, 1992) |
| Databáze: | OpenAIRE |
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